MovDisordV3, Main, Exploration, bibRecord, 000109

Presynaptic effects of levodopa and their possible role in dyskinesia.

Identifieur interne : 000109 ( Main/Exploration ); précédent : 000108; suivant : 000110

Presynaptic effects of levodopa and their possible role in dyskinesia.

Auteurs : Eugene V. Mosharov [États-Unis] ; Anders Borgkvist ; David Sulzer

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25450307

English descriptors

KwdEn :
- Animals, Dopamine (metabolism), Dopamine Agents (adverse effects), Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (metabolism), Dyskinesia, Drug-Induced (pathology), Humans, Levodopa (adverse effects), Neurons (cytology), Neurons (drug effects), Parkinson Disease (drug therapy), Presynaptic Terminals (drug effects), Presynaptic Terminals (metabolism).
MESH :
- chemical , adverse effects : Dopamine Agents, Levodopa.
- chemical , metabolism : Dopamine.
- cytology : Neurons.
- drug effects : Neurons, Presynaptic Terminals.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- metabolism : Dyskinesia, Drug-Induced, Presynaptic Terminals.
- pathology : Dyskinesia, Drug-Induced.
- Animals, Humans.

Abstract

Levodopa replacement therapy has long provided the most effective treatment for Parkinson's disease (PD). We review how this dopamine (DA) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased DA reuptake, as well as loading DA as a false transmitter into surviving serotonin neuron synaptic vesicles. We further review literature on how presynaptic dysregulation of DA release after l-dopa might trigger dyskinesias in PD patients.

DOI: 10.1002/mds.26103
PubMed: 25450307

Affiliations:

Le document en format XML

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<author><name sortKey="Mosharov, Eugene V" sort="Mosharov, Eugene V" uniqKey="Mosharov E" first="Eugene V" last="Mosharov">Eugene V. Mosharov</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Borgkvist, Anders" sort="Borgkvist, Anders" uniqKey="Borgkvist A" first="Anders" last="Borgkvist">Anders Borgkvist</name>
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<author><name sortKey="Sulzer, David" sort="Sulzer, David" uniqKey="Sulzer D" first="David" last="Sulzer">David Sulzer</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Presynaptic effects of levodopa and their possible role in dyskinesia.</title>
<author><name sortKey="Mosharov, Eugene V" sort="Mosharov, Eugene V" uniqKey="Mosharov E" first="Eugene V" last="Mosharov">Eugene V. Mosharov</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology, Columbia University Medical Center, New York, New York, USA.</nlm:affiliation>
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<author><name sortKey="Sulzer, David" sort="Sulzer, David" uniqKey="Sulzer D" first="David" last="Sulzer">David Sulzer</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Agents (adverse effects)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Dyskinesia, Drug-Induced (metabolism)</term>
<term>Dyskinesia, Drug-Induced (pathology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Neurons (cytology)</term>
<term>Neurons (drug effects)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Presynaptic Terminals (drug effects)</term>
<term>Presynaptic Terminals (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agents</term>
<term>Levodopa</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
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<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurons</term>
<term>Presynaptic Terminals</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Presynaptic Terminals</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Levodopa replacement therapy has long provided the most effective treatment for Parkinson's disease (PD). We review how this dopamine (DA) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased DA reuptake, as well as loading DA as a false transmitter into surviving serotonin neuron synaptic vesicles. We further review literature on how presynaptic dysregulation of DA release after l-dopa might trigger dyskinesias in PD patients.</div>
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<country name="États-Unis"><region name="État de New York"><name sortKey="Mosharov, Eugene V" sort="Mosharov, Eugene V" uniqKey="Mosharov E" first="Eugene V" last="Mosharov">Eugene V. Mosharov</name>
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Movement Disorders (revue)

Presynaptic effects of levodopa and their possible role in dyskinesia.

Presynaptic effects of levodopa and their possible role in dyskinesia.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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